May 12
3
Post-doctoral Position to work on
The epigenetic variation in the distribution of the transcription machinery in rat
A two years post-doctoral position is open at the Integrative Biology and Molecular Genetics Department (SBIGeM) on the Saclay campus of the CEA. The position is available immediately and will be closed when a suitable candidate is found.
The position is funded within the framework of the Euratrans project (European large-scale functional genomics in the rat for translational research; www.euratrans.eu). The project uses state-of-the-art and emerging large-scale technologies and advanced computation in an expanded multi-disciplinary approach to identify gene networks and genomic mechanisms underlying common diseases. The work will be performed in the laboratory “Transcriptional Regulation of Genomes” headed by Dr Michel Werner. Within this project, the post-doctoral fellow will investigate the genome-wide distribution of RNA polymerase II and transcription factors in tissues of rat inbred lines to discover epigenetic variations that might relate to predisposition to diseases.
The successful candidate will have a strong background in molecular biology and functional genomics. Prior knowledge in the analysis of high throughput sequencing data will be an advantage.
The laboratory is located southwest of Paris (France). Information can be found on the web sites of the team http://www-dsv.cea.fr/ibitecs/sbigem/lrege/transcription.
Interested candidates should contact: Dr. Michel Werner +33-(0)1 6908 9342 / michel.werner@cea.fr
Selected references of the team:
Carrière et al. (2012) Genomic binding of Pol III transcription machinery and relationship with TFIIS transcription factor distribution in mouse embryonic stem cells. Nucl. Acids Res. 40, 270-283.
Soutourina, J. et al. (2011) Direct RNA polymérase II – Mediator interaction required for transcription in vivo. Science, 331, 1451-1454.
Esnault, C. et al. (2008) Mediator-dependent recruitment of TFIIH modules in preinitiation complex. Mol. Cell 31, 337-346.
Ghavi-Helm, Y. et al. (2008) Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription. Genes Dev. 22, 1934-1947.
Guglielmi, B. et al. (2007) TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Proc. Natl. Acad. Sci. USA 104, 16062-16067.
