Jun 12
12
Post-doctoral position in the Humbert lab
The laboratory is focusing on mechanisms of cell division and polarity through the study of huntingtin, the protein mutated in the neurodegenerative disorder Huntington’s disease. We identified huntingtin as a key player during neuronal progenitors division and differentiation with consequences during mouse embryonic cortical neurogenesis. The main focus of the laboratory is to decipher the role of huntingtin during developmental and adult neurogenesis in physiological and Huntington’s disease pathophysiological conditions.
We are looking for a highly qualified and motivated scientist. The successful candidate should have experience in cell and molecular biology. Additional knowledge in signal transduction, neurobiology and/or use of mouse models would be a bonus.
The laboratory is part of the Curie Institute, the Inserm and the CNRS. It is located in Orsay in the University campus, close to the CNRS center of Gif/Yvette and 40 min to downtown Paris.
Candidates should send a curriculum vitae, a brief summary of research experience and interest, and contact informations for 2-3 referees to: Dr. Sandrine HUMBERT, sandrine.humbert@curie.fr
Publications
Godin, J.D., Poizat, G., Hickey, M.A., Maschat, F. and Humbert S. (2010). Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J., 29, 2433-2445.
Godin, J.D., Colombo, K., Molina-Calavita, M., Keryer, G., Zala, D., Charrin, B.C., Dietrich, P., Volvert, M.L., Guillemot, F., Dragatsis, I., Bellaiche, Y., Saudou, F., Nguyen, L. and Humbert, S. (2010). Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron, 67, 392-406.
