Feb 12
21
Laboratory for Molecular Cell Biology
Cell Biology Unit, University College London, UK
Postdoctoral Position in the group of Dr. Franck Pichaud
Cell Polarity & Morphogenesis
Cell polarity is a widespread feature of living organisms that is crucial to enable organogenesis, directed cell migration and neural circuit formation to name just a few examples. Our research is aimed at characterizing the molecular and cellular mechanisms involved in epithelial and neuronal polarity remodeling during development.
This position is to focus on the problem of polarized axon growth in vivo, a process that is absolutely required alongside neuronal migration to enable neural function and neural circuit formation respectively. We have recently developed a new high throughput, in vivo assay using Drosophila to study neuronal migration and axon growth on a genome-wide scale. We have also already identified several candidate factors involved in these processes in vivo. The proposed work will involved a genome-wide screening using RNAi in vivo, as well as a number of candidate approaches. The candidate will also be involved in setting up state of the art imaging approaches such as super-resolution microscopy (OMX & STED) together with 3D-view electron microscopy applied to studying polarized axon growth during development.
This position is a 3 years MRC funded Career Development Fellowship (CDF) available in our group. Applications including a cover letter, CV and contact details of at least 2 referees should be sent to f.pichaud@ucl.ac.uk. Successful candidates will be expected to be internationally competitive, including having published at least one peer
reviewed publication as first author. Previous experience in Drosophila genetics would be advantageous but is not absolutely required.
